New development for lab automation: APD tool from Syntegon identifies optimal process parameters for tablet presses

New development for lab automation: APD tool from Syntegon identifies optimal process parameters for tablet presses

Syntegon Technology GmbH
Automated test runs thanks to innovative powder feeding system Realistic simulation of subsequent production conditions Optimal process parameters determined on an exact data basis

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Waiblingen/Germany, October 5, 2022. After the successful launch of the Automated Process Development (APD) tool for capsule filling processes in 2020, Syntegon is now expanding this expertise for tablet presses. The new, automatically adjustable powder feeder and the APD software offer pharmaceutical manufacturers a complete package to determine the ideal process parameters for each product and easily transfer them to production machines. “While manual analyses used to take days or even weeks, the APD tool achieves faster and more precise results with much less product,” says Matthias Moessinger, Senior Market Expert Pharma Solid at Syntegon.

Simulating exact process parameters
“Tablets have a significantly higher number of relevant parameters and quality attributes compared to capsules – from shape or diameter to thickness and hardness, numerous properties play an important role,” Moessinger explains. “In the first step, we focused on powder feeding and the various feeder designs; others will follow.” The new powder feeding system is specifically tailored to the TPR 200 tablet press from Syntegon. The system can be adjusted automatically to fit every possible stirrer configuration. The impellers have a square and a round side to reflect factors such as the influence of powder movement on tablet properties. In addition, the speed and direction of rotation as well as the inclination of the stirrer blades can be varied.

Faster time to market with laboratory automation
During the product tests, the APD software evaluates and optimizes the process parameters regarding their influence on critical quality attributes. As a major highlight, both the changeover of the feeding system and the tests are fully automated; human intervention is no longer necessary. The APD tool is based on Design of Experiments (DoE) and analyzes the functional relations between material properties, process parameters and… Read more: Press » Syntegon

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